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The Best Fish to Eat on GLP-1 Medications

(And Why Tuna & Salmon Top the List) 


June 15, 2026

Starting a GLP-1 medication like Ozempic, Wegovy, or Zepbound is a big step. For many people, it comes with a mix of hope, relief, and — let’s be honest — a fair amount of uncertainty. What am I supposed to eat now? How do I make sure I’m still getting enough nutrients? 
What if I do this wrong?

If that sounds familiar, you’re not alone. And you’re asking exactly
the right questions.

Here’s the reassuring truth: you don’t need a complicated plan. 
You need a few nutrient-dense foods you can rely on — foods that work hard for your body even when your appetite is quiet. And fish, particularly wild-caught tuna and salmon, belongs at the top 
of that list.

Why What You Eat on a GLP-1 Matters More Than You Think

GLP-1 medications work by slowing digestion, reducing hunger signals, and helping regulate blood sugar. Most people on GLP-1s naturally eat significantly
less — sometimes dramatically less — than they did before. That’s part of how they work.

But here’s what doesn’t change: your body’s need for protein, healthy fats, vitamins, and minerals. In fact, those needs may be even higher now, because your body is actively working to lose weight and preserve muscle at the same time.

A recent study presented at the European Congress on Obesity found that real-world GLP-1 users had critically low protein intake and frequently skipped meals altogether — creating a serious risk of muscle loss and nutritional deficiencies.1 And research published in Current Developments in Nutrition found that several key micronutrients, including vitamin B12, vitamin D, iron, magnesium, and omega-3 fatty acids, are commonly under-consumed during active weight loss.3
“Protecting muscle mass should be a central goal of any weight-loss program,” said lead study author Valentina Vinelli of IRCCS San Raffaele Hospital. “Muscle health depends on sufficient protein intake and regular physical activity, especially resistance exercise.”

When it comes to GLP-1 diet protein intake, nutrition experts recommend aiming for around 1.2 to 1.6 grams of protein per kilogram of body weight per day while on a GLP-1.2 For a 150-pound person, that’s roughly 80–110 grams of protein daily — a target that’s hard to hit when you’re eating smaller portions. According to the National Institutes of Health, adequate protein intake is essential during weight loss to help preserve lean body mass.11 This is why the quality of what you eat becomes everything.

Every meal is an opportunity. Make it count.

Why Fish Is One of the Best Foods to Eat on GLP-1 Medications

When your appetite is reduced and your meals are smaller, you need foods that deliver a lot of nutrition in a small package. For anyone researching the best foods
for an Ozempic diet, especially high-protein options for GLP-1 users, wild-caught fish consistently tops the list — and for good reason.

Here’s why fish is such a natural fit for GLP-1 users:

  • It’s packed with complete protein. Fish provides all the essential amino acids your body needs to maintain and repair muscle — which is especially critical during weight loss, when the body can break down muscle tissue if protein intake is too low.
  • It’s rich in omega-3 fatty acids. EPA and DHA — the omega-3s found in fatty fish — support heart health, reduce inflammation, and play a role in brain function. These are nutrients that many GLP-1 users aren’t getting enough of.
  • It helps your medication work better. Ohio State University’s Wexner Medical Center notes that eating healthy fats and omega-3s found in fish like tuna and salmon can actually increase the body’s natural GLP-1 hormone release, helping you feel fuller for longer.4
  • It’s easy on a sensitive stomach. Greasy, fried, and heavily processed foods are among the biggest triggers for GLP-1 side effects like nausea and bloating. 
Wild-caught fish is the opposite — lean, clean, and gentle on digestion.
  • It fills critical nutrient gaps. Fish is one of the best natural sources of vitamin B12, vitamin D, and selenium — three nutrients that are commonly low in GLP-1 
users.3 Learn more about the full nutritional benefits of Safe Catch seafood.

GLP-1 Nutrition

Cheat Sheet

Simple, smart foods to support your GLP-1 journey.
PROTEIN INTAKE TARGET
1.2-1.6g
per kg body weight
Supports lean muscle, energy, and overall well-being while 
losing weight.
Best Foods
Best Foods

TUNA

High-quality protein and rich in essential nutrients.

SALMON

Packed with protein and heart-healthy omega-3s.

EGGS

Complete protein with essential vitamins and minerals.

LEAFY GREENS

High in fiber, vitamins, and minerals to support your health.

EAT PROTEIN FIRST

Starting your meal with protein can help you feel fuller,
support muscle, and make the most of every meal.

Tuna: Your New Go-To Protein

If there’s one food that was practically designed for a GLP-1 diet, it’s tuna. A single 3-ounce serving of Safe Catch Elite Wild Tuna packs 24 grams of high-quality protein — right in line with the 20–30g per meal recommended for GLP-1 users,14 without requiring a large or heavy meal.

And the nutrition doesn’t stop at protein. Tuna also delivers:

  • Vitamin B12 — essential for energy, mood, and nerve function
  • Selenium — a powerful antioxidant that supports immune health
  • Niacin — which plays a key role in metabolism
  • Omega-3 fatty acids (EPA & DHA) — for heart and cognitive support

For someone newly on a GLP-1, canned tuna is also one of the most practical proteins you can keep in your kitchen. No cooking required. No planning ahead. On the days when your appetite is low and the thought of preparing a meal feels like too much, opening a can of tuna and eating it over greens with a drizzle of olive oil is enough — simple, satisfying, and nourishing.

NBC News medical contributor Dr. Natalie Azar recommends consuming 20–30 grams of protein per meal every day for those on GLP-1 medications.14 A serving of 
Safe Catch Elite Wild Tuna delivers 24g of clean protein per serving (40g per can), with no fillers, no added water, and nutrients naturally preserved through its 
slow-cooked, do-not-drain process. Each can is also hand-packed to help retain natural nutrients and flavor — making it one of the most nutrient-dense high-protein foods for GLP-1 users on the market.

A Word on Mercury — Because It Matters

Here’s something worth knowing, especially if you plan on eating tuna regularly: not all canned tuna carries the same mercury risk. Mercury is a neurotoxin that accumulates in fish tissue over time, and independent research has shown significant variation in mercury levels from can to can — even within the same brand.5

For GLP-1 users eating fish multiple times a week as a primary protein source, this matters more than it might for an occasional tuna sandwich. Choosing a brand that actually tests for mercury isn’t just a nice-to-have; it’s a genuinely smart health decision.

Safe Catch is the only brand that tests every single tuna for mercury — 100% of fish, every time.6 Safe Catch Elite Wild Tuna is tested to a mercury limit of 0.1 ppm — 10x lower than the FDA’s action level. Safe Catch Wild Ahi Yellowfin Tuna is also mercury tested to 0.1 ppm, equally 10x lower than the FDA’s action level.6

Safe Catch’s mercury testing technology is also certified by AOAC Research Institute — the global gold standard for verifying scientific testing methods. Over 13 million fish have been tested, and about 1 in 4 tuna do not meet our purity standards.

When you’re already making thoughtful choices about what goes into your body, it makes sense to know exactly what’s in your tuna.

Mercury Levels Vary Widely in Canned Light Tuna (Skipjack)

Consumer Reports’ “Low Mercury” Criteria Low Mercury standard for women (16-49), pregnancy, and children​

Source: Safe Catch mercury testing data vs. published research. Learn more about Safe Catch mercury testing →

Salmon: The Omega-3 Powerhouse Your Body Is Asking For

If tuna is your everyday protein, salmon is your long-game investment. Rich in both protein and omega-3 fatty acids, salmon offers a nutritional profile that’s especially valuable for GLP-1 users thinking beyond weight loss — toward lasting heart, brain, and metabolic health.

A three-ounce serving of Safe Catch Wild Pacific Pink Salmon provides 18 grams of protein, plus meaningful amounts of EPA and DHA omega-3s that support heart, brain, and metabolic health.7 If you’re wondering whether whole fish or supplements are the better source, this breakdown of fish vs. fish oil omega-3s is worth a read. A large-scale study of over 217,000 adults found a potential link between higher omega-3 blood levels and a 35–40% reduced risk of developing early-onset dementia, regardless of genetic predisposition.8

Not all salmon is nutritionally equal — and for GLP-1 users prioritizing clean, nutrient-dense eating, the distinction between wild-caught and farmed matters. 
Wild-caught salmon feeds on a natural diet of smaller fish and plankton, resulting in a leaner protein with higher natural mineral content and a more favorable omega-3 to omega-6 ratio.12 Farmed salmon, by contrast, are increasingly fed plant-based and grain-based diets. This elevates omega-6 levels — which can work against 
the anti-inflammatory benefits you’re eating fish for in the first place.13

“Fatty fish — especially salmon — are rich in DHA and EPA omega-3 fatty acids, good for heart, brain, and eye health. With reduced appetite on GLP-1s, foods that deliver this much nutrition per bite are especially valuable.” — Liz Weiss, RDN, co-author of The GLP-1 Kitchen9

Beyond omega-3s, salmon is also one of the best dietary sources of Vitamin D — a nutrient that tends to be low in people managing higher body weight, and one that plays a key role in immune function, mood, and bone health.3

Safe Catch Wild Pacific Pink Salmon delivers 18g of protein per serving (30g per can) and is individually tested to a mercury limit of 0.04 ppm — 25x stricter than the FDA’s action level. Same rigorous testing. Same commitment to purity. Just as easy to keep on hand as a can of tuna.

It’s also worth noting that Safe Catch is the Official Seafood Partner of the American Pregnancy Association — a recognition that speaks directly to the brand’s commitment to purity for people who need to be most careful about what they consume.

Tuna vs. Salmon: Do You Have to Choose?

Short answer: you don’t. And you probably shouldn’t.

Tuna
Salmon
Protein per serving
24–26g
18g
Protein per can
40–43g
30g
Omega-3s (EPA+DHA)
Moderate
Very High
Vitamin D
Moderate
High
Vitamin B12
High
High
Safe Catch mercury testing limit
0.1 ppm (10x stricter than FDA)6
0.04 ppm (25x stricter than FDA)6
Best for
Quick protein-first meals
Omega-3, heart & brain health

Protein per serving, protein per can, and mercury testing limit figures reflect Safe Catch product standards. Omega-3s, Vitamin D, and Vitamin B12 values are based on wild-caught fish general nutritional profile.7

Rotating between tuna and salmon throughout the week is one of the simplest, most effective nutrition strategies for someone on a GLP-1. You get the protein density of tuna and the omega-3 richness of salmon — covering more nutritional ground without complicating your routine.

How Often Should You Eat Fish on a GLP-1 Diet?

The Dietary Guidelines for Americans recommend that most adults eat at least 8 ounces — about two servings — of fish per week.10 For GLP-1 users with elevated protein needs and reduced food intake, building fish into the diet three to four times a week is a practical and sustainable approach.
The key is variety and consistency — not perfection. You don’t need to overhaul your diet overnight. Simply swapping one or two meals a week to include wild-caught tuna or salmon is a meaningful step in the right direction.

What to Avoid Eating on GLP-1 Medications

Knowing what to eat on GLP-1 medications is just as important as knowing what to limit. Certain foods can worsen side effects, spike blood sugar, or crowd out the nutrients your body needs most:

  • Fried foods — Heavy oils trigger nausea and digestive discomfort, two of the most common GLP-1 side effects
  • Ultra-processed foods — Low in nutrients and high in additives; they fill you up without giving your body anything useful
  • High-sugar foods and drinks — Cause blood sugar spikes that work against what your medication is designed to do
  • Heavy cream-based meals — Rich, fatty sauces and dishes can slow digestion further and worsen bloating
  • Refined carbohydrates — White bread, white rice, and crackers offer little nutrition and can destabilize blood sugar
  • Alcohol — Adds empty calories, stresses the liver, and can amplify GLP-1 side effects


The pattern is simple: the best foods for an Ozempic diet are whole, minimally processed, and nutrient-dense. The worst are the opposite. When in doubt, ask yourself: does this food work for my body or just fill space?

WHAT TO EAT

AVOID ON GLP-1

Simple, smart foods to support your GLP-1 journey.
Eat More

Tuna

Salmon

Eggs

Leafy Green

Fuel your body. Support your results.
Limit or Avoid

FRIED FOODS

SUGARY FOODS

ULTRA- PROCESSED FOODS

CREAM- BASED DISHES

These may cause discomfort and slow your progress.

Simple, Low-Effort Ways to Eat More Fish

One of the most common challenges on a GLP-1 is that even thinking about cooking can feel overwhelming when you’re not hungry. These ideas require minimal effort and still deliver real nutrition. For even more inspiration, browse Safe Catch’s full recipe collection — designed for real life, not just ideal days.

  • Tuna over greens — Open a can of Safe Catch tuna, flake over arugula or spinach, drizzle with olive oil and lemon. Two minutes. High in protein 
and ready in no time.
  • Salmon & avocado bowl — Safe Catch salmon over brown rice with sliced avocado and a drizzle of tamari. Protein, healthy fat, and fiber in one bowl.
  • Tuna cucumber bites — Spoon Safe Catch tuna onto cucumber rounds with a squeeze of lemon. Light, no-cook, and easy to eat in small amounts 
on low-appetite days.
  • Salmon scramble — Stir Safe Catch salmon into scrambled eggs. A protein-packed breakfast that takes under five minutes.
  • Tuna stuffed avocado — Mix Safe Catch tuna with Greek yogurt and herbs, spoon into half an avocado. Satisfying in a small portion.
  • Salmon white bean soup — Simmer Safe Catch salmon with white beans, broth, garlic, and spinach. Warm, easy on the stomach, and rich in both protein and fiber.


One simple rule to remember: eat protein first. Whatever’s on your plate, start with the fish. If you fill up quickly — which you likely will — the most important 
nutrient is already in.

You’re Making a Thoughtful Choice. Your Food Should Too.

Starting a GLP-1 journey takes courage. It’s a decision made out of care for your own health, and it deserves to be supported by food that meets that same standard of intention.

You don’t need to eat perfectly. You don’t need a complicated meal plan or a pantry full of superfoods. What you need is a handful of reliable, nourishing options you can reach for on the hard days and the good ones alike.

Wild-caught fish — mercury tested and thoughtfully sourced, with a focus on purity and nutrition — is one of the best things you can put on your plate right now. Not because of a trend, and not because of a label. Because your body is working hard, and it deserves food that works just as hard in return.

When you’re ready to make fish a regular part of your routine, look for wild-caught options from a brand that tests every single tuna and salmon for mercury — not random samples, every fish. That level of mercury testing, transparency, and nutritional integrity is what separates a genuine commitment to purity from a marketing claim — from fish that’s sustainably sourced and MSC certified to fish that delivers real nutrition without hidden concerns.  That’s what eating well on a GLP-1 actually looks like — and it’s simpler than you might think.


Curious about the story behind Safe Catch and why mercury testing became our mission? Read our story here.

Frequently Asked Questions

What foods should you eat on GLP-1 medications?
Focus on high-protein, nutrient-dense whole foods like fish, eggs, lean meats, legumes, and vegetables. These foods support muscle preservation, fill common nutrient gaps, and are gentle on digestion — all critical priorities when eating less overall.3

How much protein do you need on Ozempic or Wegovy?
Most nutrition experts recommend 1.2–1.6g of protein per kilogram of body weight per day during active weight loss on a GLP-1.2 For a 150-pound person, that’s roughly 80–110 grams daily. Spreading protein across all meals — starting with protein first — is the most effective approach.

Is tuna good for a GLP-1 diet?
Yes. Tuna is one of the best high-protein foods for GLP-1 users — an excellent source of protein, omega-3 fatty acids, and essential nutrients like B12 and selenium, all in a low-calorie, easy-to-digest package. Safe Catch Elite Wild Tuna, for example, delivers 24g of protein per serving. When choosing canned tuna, opt for a brand that individually tests every single fish for mercury, especially if you plan to eat it regularly.

Can you eat salmon on GLP-1 medications?
Absolutely. Salmon provides both high-quality protein and omega-3 fatty acids (EPA and DHA), which support heart health, reduce inflammation, and may even help enhance the body’s natural GLP-1 response.4, 7 It’s one of the most nutritionally complete foods you can eat on this journey.

What to eat on GLP-1 medications when you have no appetite?
This is one of the most common challenges. Keep easy, no-cook options on hand — when appetite is low and you’re eating fish more frequently as your main protein source, choosing a brand that individually tests every tuna and salmon for mercury — like Safe Catch — gives you one less thing to worry about. Eating small amounts of protein-first meals throughout the day is more sustainable than forcing three large meals when appetite is low.

Always consult your healthcare provider or a registered dietitian for personalized nutrition guidance while taking GLP-1 medications.

All health and nutrition claims in this article are supported by peer-reviewed research and official government health guidance.

  1. Vinelli V, et al. AI-based monitoring reveals protein deficiencies in people taking GLP-1 receptor agonists for weight loss. European Association for the Study of Obesity. 2026.
  2. Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, et al. Nutritional priorities to support GLP-1 therapy for obesity: a joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Obesity (Silver Spring). 2025;33(8):1475–1503. PubMed, NIH.
  3. Johnson B, McGlasson T, Thomas O, Kreider R, Jones R. Suboptimal protein intake for hypocaloric diet needs while using glucagon-like peptide-1 receptor agonists. J Int Soc Sports Nutr. 2025;22(Suppl 2):2550139. PMC, NIH.
  4. Tips for activating your GLP-1 levels naturally. Ohio State University Wexner Medical Center. 2025.
  5. Gerstenberger SL, Martinson A, Kramer JL. An evaluation of mercury concentrations in three brands of canned tuna. Environ Toxicol Chem. 2010;29:237–242. PubMed, NIH.
  6. How much mercury is in your products? Safe Catch.
  7. Omega-3 fatty acids: an essential contribution. Harvard T.H. Chan School of Public Health.
  8. Wei BZ, Li L, Dong CW, Tan CC, Xu W. The relationship of omega-3 fatty acids with dementia and cognitive decline. Am J Clin Nutr. 2023;117(6):1096–1109. PMC, NIH.
  9. Weiss L. Quoted in Food Network Health. 7 dietitian-recommended foods to make sure you’re eating if you’re on a GLP-1. 2025.
  10. Dietary Guidelines for Americans, 2020–2025. U.S. Department of Agriculture & U.S. Department of Health and Human Services. 2020.
  11. Hector AJ, Phillips SM. Protein recommendations for weight loss in elite athletes: a focus on body composition and performance. Int J Sport Nutr Exerc Metab. 2018;28(2):170–177. PubMed, NIH.
  12. Foran JA, Good DH, Carpenter DO, Hamilton MC, Knuth BA, Schwager SJ. Quantitative analysis of the benefits and risks of consuming farmed and wild salmon. J Nutr. 2005;135(11):2639–2643. PubMed, NIH.
  13. Lundebye AK, Haldorsen S, Huang TS, Hevrøy EM, Hamre K. An update on the content of fatty acids, dioxins, PCBs and heavy metals in farmed, escaped and wild Atlantic salmon. Foods. 2020;9(12):1901. PMC, NIH.
  14. Can certain foods impact your Ozempic side effects? Cleveland Clinic. 2024.
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